pymeleleki's picture
Patrick
Ymele-Leki

Contact

Office: 
LK Downing Hall, Rm 2011
Phone: 
(202) 806-4811
Email: 
patrick.ymeleleki@howard.edu

Faculty Details

Rank: 
Assistant Professor
Education: 

University of Maryland Baltimore County, Chemical Engineering, PhD, 2009
University of Maryland Baltimore County, Chemical Engineering, BS (Summa Cum Laude), 2003
Montgomery College, Chemical Engineering, AS (With Honors), 2001
Faculté Libre de Sciences, Life and Earth Sciences, AS, 1998

Specialty: 

Bacterial adhesion, microfluidic systems, biofilm engineering, infectious diseases, drug discovery, high/low throughput screening

Research: 

Our long-term goal is to enhance current antimicrobial arsenal and further understanding of complex microbial communities.

Our research program focuses on (i) the development and implementation of high‐ and low- throughput screening assays for the identification of novel small molecules with antimicrobial activity, (ii) the development and characterization of physiologically and industrially relevant multispecies in vitro biofilm models for the identification of potential drug targets, and (iii) the in vivo assessment of cytotoxicity and pharmacokinetics parameters and hypothesis‐driven validation of antimicrobial drug targets for site colonization related to biofilm formation. This approach combines the benefits of physiologically and industrially relevant assays with a target validation approach superior to that typically encountered for either drug discovery screening or biofilm resistance studies.

Current work and collaborative research projects include (i) the investigation of the impact of biofilm structural features (i.e., porosity, diffusional distance, biomass, and biovolume) and physical fluid forces on the efficacy of known antimicrobial agents; (ii) the evaluation of potential antimicrobial challenge mechanisms as a strategy for in situ biofilm control; and (iii) the identification of novel chemical probes and microbial targets and development of novel drug delivery strategies in biofilm settings. Further details are available on our laboratory website

These studies have applications in medical, pharmaceutical, and biotechnological sciences.

Subjects Taught: 

Introduction to Biomedical Engineering
Introduction to Engineering Design
Advanced Thermodynamics
Chemical Engineering Laboratory
Independent Study in Chemical Engineering
Heat Transfer
Fluid Mechanics

Detailed Information

About Me: 

Appointments and Affiliations
2012-Present Assistant Professor of Chemical Engineering, Howard University
2009 Lecturer, Chemical Engineering, University of Maryland Baltimore County
2003-2005 Teaching Assistant, Chemical Engineering, University of Maryland Baltimore County

Awards, Honors, and Distinctions
2014 2014 Provost Research Resources and Small Equipment Award
2006 Center of Biofilm Engineering Summer School Scholarship (MSU)
2004 Grosvenor Inc. Graduate Fellowship (UMBC)
2003 Outstanding Senior in Chemical Engineering (UMBC)
2003 UMBC Alumni Outstanding Student Award
2003 Local Chapter AIChE Award for Undergraduate Talk
2001 United States Achievement Academy (USAA) National Award (MC)
2001 Paul Peck Humanities Internship Award (MC)
2001 Recognition for Academic Excellence in Honors Curricula (MC)
2000, 2001 Dr. Harry Harden, Jr. Black & African American Academic Awards (MC)
2000, 2001 The R.B. Woodward Memorial Organic Chemistry Award (MC)
1999-2001 Dean’s list at Montgomery College (MC, all semesters)

Patents
Paula I. Watnick, Patrick Ymele-Leki, Jon Clardy, Shugeng Cao. Natural Product Antibiotics and Analogs Thereof. U. S. Patent. 9,359,275. [Link]

Representative Publications
1. Stanley S, P Ymele-Leki. Introducing High School Students to Chemical Engineering Kinetics With a Simple Experiment-Based Smartphone Education Application. Chemical Engineering Education. 2017 Fall; 51(4): 189-197. [Link]

2. Fennell Y, P Ymele-Leki, TA Adegboye, KL Jones. Impact of sulfidation of silver nanoparticles on established P. aeruginosa biofilms. J Biomaterials and Nanobiotechnology. 2017 Jan;8(1):83-95. [Open Access]

3. Ymele-Leki P, L Houot, PI Watnick. Mannitol and the mannitol-specific enzyme IIB subunit activate Vibrio cholerae biofilm formation. Appl Environ Microbiol. 2013 Aug;79(15):4675-83. [PMID: 23728818]

4 . Absalon C, P Ymele-Leki, PI Watnick. The bacterial biofilm matrix as a platform for antigen presentation and enzyme delivery. MBio. 2012 Jul 17;3(4):e00127-12. [PMID: 22807566]

5. Py BF, SF Gonzalez, K Long, MS Kim, YA Kim, H Zhu, J Yao, N Degauque, R Villet, P Ymele-Leki, M Gadjeva, GB Pier, MC Carroll, J Yuan. Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. Immunity. 2013 May 23;38(5):1063-72. [PMID: 23684986]

6. Ymele-Leki P, S Cao, J Sharp, K Lambert, A McAdam, R Husson, G Tamayo, J Clardy, PI Watnick. A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. PLoS ONE. 2012;7(2):e31307. [PMID: 22359585]

7. Acosta MA, P Ymele-Leki, Y Kostov, JB Leach (2009). Fluorescent microparticles for sensing cell microenvironment oxygen levels within 3D scaffolds. Biomaterials, 30(17):3068-74. [PMID: 19285719]

8. George NPE, P Ymele-Leki, K Konstantopoulos, JM Ross (2009). Differential binding of biofilm-derived versus suspension grown Staphylococcus aureus to immobilized platelets in shear flow. Journal of Infectious Diseases, 199(5):633-40. [PMID: 19210161]

9. Ymele-Leki P, JM Ross (2007). Erosion from Staphylococcus aureus biofilms grown under physiologically relevant fluid shear forces yields bacterial cells with reduced avidity to collagen. Applied and Environmental Microbiology, 73(6): 1834-1841. [PMID: 17277217]

10. Mascari L, P Ymele-Leki, CD Eggleton, P Speziale, JM Ross (2003). Fluid shear contributions to bacteria cell detachment initiated by a monoclonal antibody. Biotechnology and Bioengineering, 83(1): 65-74. [PMID: 12740934]

News

Assistant Professor Patrick Ymele-Leki Mentors Postdoctoral Researcher and 2018 Research Week Winner

Fri, April 20, 2018

Chemical Engineering postdoctoral researcher Jyothirmai Simhadri was announced as the Post Doc/Resident/Fellow/Research Associate winner in the Physical Sciences and Engineering category for her research submission titled: Development of Shewanella Oneidensis MR-1 Biofilms for Iodate Reduction in Groundwater. Read More >>

Howard, Bajracharya & Shakya Win 2017 ExxonMobil/AIChE-NCS Award

Tue, April 3, 2018

Seniors April Howard, Diwash Bajracharya, and Preety Shakya (pictured left to right) were the 2017 recipients of the ExxonMobil/AIChE-NCS Award.Read More >>

Events

May122018
Commencement